Allogene Therapeutics Enters Lease to Build 118,000 SQFT Manufacturing Facility in Newark, CA

Allogene Therapeutics, Newark, Silicon Valley, CBRE, Kidder Matthews, San Francisco,

(EDITOR’S NOTE: The advanced manufacturing project is developed by Panattoni Development and Clarion Partners. Jason Ovadia, Greg Matter, David Sesi and Chelsey Williams of JLL represented the owners in the transaction).

SOUTH SAN FRANCISCO, Calif., (Feb. 20, 2019) — Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T™) therapies for cancer, today announced that it has entered into a lease agreement to develop a 118,000 square foot cell therapy manufacturing facility in Newark, California.

“Building state-of-the-art manufacturing capabilities is at the core of our strategy to deliver readily available cell therapy faster, more reliably and at greater scale,” said Alison Moore, Ph.D., Chief Technical Officer of Allogene. “This manufacturing facility and continued build out of our in-house process development and characterization capability will allow us to advance manufacturing and secure the supply of our AlloCAR T™ therapies.”

The new manufacturing facility is being designed to provide GMP manufacturing for clinical supply and commercial product upon potential regulatory approval. Allogene currently manufactures its clinical trial supply through a contract manufacturing organization, which continues to remain a component of the company’s long-term manufacturing strategy.

The manufacturing of AlloCAR T™ therapy begins with harvesting T cells from healthy donors. Donor T cells are engineered to express chimeric antigen receptors (CARs), which are designed to recognize certain cell surface proteins expressed on hematologic or solid tumors. Genes within T cells are then edited to reduce the risk of graft versus host disease (GvHD) and allogeneic rejection. Engineered AlloCAR T™ cells undergo expansion and are ultimately cryopreserved for on demand delivery to patients.

The facility is part of the Gateway 84 Silicon Valley advanced manufacturing campus currently under construction. Allogene was represented by CBRE Inc. and Kidder Matthews.

About Allogene Therapeutics
Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T™) therapies for cancer. Led by a world-class management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell therapy candidates with the goal of delivering readily available cell therapy faster, more reliably and at greater scale to more patients.

AlloCAR T™ cell therapies are engineered from cells of healthy donors, which is intended to allow for creation of inventory for on demand use in patients. This approach is designed to eliminate the need to create personalized therapy from a patient’s own cells, simplify manufacturing, and reduce the time patients must wait for CAR T cell treatment. The Allogene portfolio includes rights to 16 pre-clinical CAR T cell therapy assets and AlloCAR T™ therapy candidates ALLO-501 and UCART19. Allogene is the sponsor of the ALLO-501 program which is expected to begin Phase 1 in the first half of 2019 for the treatment of relapsed/refractory non-Hodgkin lymphoma (NHL). Servier is the sponsor of the UCART19 program which is currently in Phase 1 for the treatment of relapsed/refractory acute lymphoblastic leukemia (ALL). For more information, please visit

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